While the management of Philadelphia-positive Acute Lymphoblastic Leukaemia (Ph+ ALL) has evolved over the last decades, new and exciting treatments becomes increasingly available. Prof. Foa, who is the lead of the GIMEMA trial, will be sharing with us the exciting latest outcome from GIMEMA trial, long-term follow up of chemo-free treatment for Ph+ALL, and latest advances on MRD-guided treatment for both Ph- and Ph+ ALL.